2023

Burgess, S., Davey Smith, G., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Kutalik, Z., Holmes, M. V., Minelli, C., Morrison, J. V., Pan, W., Relton, C. L. & Theodoratou, E. Guidelines for performing Mendelian randomization investigations: update for summer 2023. Wellcome Open Research 4, 186 (Aug. 4, 2023).

Metabolome-wide MR study:

Yin, X., Li, J., Bose, D., Okamoto, J., Kwon, A., Jackson, A. U., Fernandes, L. F., Oravilahti, A., Stringham, H. M., Ripatti, S., Daly, M., Palotie, A., Scott, L. J., Burant, C. F., Fauman, E. B., Wen, X., Boehnke, M., Laakso, M. & Morrison, J. Metabolome-wide Mendelian randomization characterizes heterogeneous and shared causal effects of metabolites on human health. MedRxiv: 2023.06.26.23291721. (June 2023) Preprint

Wang, L., Wen, X. & Morrison, J. Imperfect gold standard gene sets yield inaccurate evaluation of causal gene identification methods. en. bioRxiv: 2023.05.04.539407. Under consideration at Nature Communications (May 2023). Preprint

Okamoto, J., Wang, L., Yin, X., Luca, F., Pique-Regi, R., Helms, A., Im, H. K., Morrison, J. & Wen, X. Probabilistic integration of transcriptome-wide association studies and colocalization analysis identifies key molecular pathways of complex traits. The American Journal of Human Genetics 110. PMCID: PMC9892769, 44–57 (Jan. 2023).

2022

Yin, X., Bose, D., Kwon, A., Hanks, S. C., Jackson, A. U., Stringham, H. M., Welch, R., Oravilahti, A., Fernandes Silva, L., Locke, A. E., Fuchsberger, C., Service, S. K., Erdos, M. R., Bonnycastle, L. L., Kuusisto, J., Stitziel, N. O., Hall, I. M., Morrison, J., Ripatti, S., Palotie, A., Freimer, N. B., Collins, F. S., Mohlke, K. L., Scott, L. J., Fauman, E. B., Burant, C., Boehnke, M., Laakso, M. & Wen, X. Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk. en. The American Journal of Human Genetics 109. PMCID: PMC9606383, 1727–1741 (Oct. 2022).

Yin, X., Chan, L. S., Bose, D., Jackson, A. U., VandeHaar, P., Locke, A. E., Fuchsberger, C., Stringham, H. M., Welch, R., Yu, K., Fernandes Silva, L., Service, S. K., Zhang, D., Hector, E. C., Young, E., Ganel, L., Das, I., Abel, H., Erdos, M. R., Bonnycastle, L. L., Kuusisto, J., Stitziel, N. O., Hall, I. M., Wagner, G. R., Kang, J., Morrison, J., Burant, C. F., Collins, F. S., Ripatti, S., Palotie, A., Freimer, N. B., Mohlke, K. L., Scott, L. J., Wen, X., Fauman, E. B., Laakso, M. & Boehnke, M. Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci. en. Nature Communications 13. PMCID: PMC8960770, 1644 (Mar. 2022).

MR Review:

Sanderson, E., Glymour, M. M., Holmes, M. V., Kang, H., Morrison, J., Munafò, M. R., Palmer, T., Schooling, C. M., Wallace, C., Zhao, Q. & Davey Smith, G. Mendelian randomization. en. Nature Reviews Methods Primers 2. PMCID: PMC7614635, 1–21 (Feb. 2022). pdf

2020

Sakabe, N. J., Aneas, I., Knoblauch, N., Sobreira, D. R., Clark, N., Paz, C., Horth, C., Ziffra, R., Kaur, H., Liu, X., Anderson, R., Morrison, J., Cheung, V. C., Grotegut, C., Reddy, T. E., Jacobsson, B., Hallman, M., Teramo, K., Murtha, A., Kessler, J., Grobman, W., Zhang, G., Muglia, L. J., Rana, S., Lynch, V. J., Crawford, G. E., Ober, C., He, X. & Nóbrega, M. A. Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth. en. Science Advances 6. PMCID: PMC7710387, eabc8696 (Dec. 2020).

Zhang, Z., Luo, K., Zou, Z., Qiu, M., Tian, J., Sieh, L., Shi, H., Zou, Y., Wang, G., Morrison, J., Zhu, A. C., Qiao, M., Li, Z., Stephens, M., He, X. & He, C. Genetic analyses support the contribution of mRNA N 6 -methyladenosine (m 6 A) modification to human disease heritability. en. Nature Genetics 52. PMCID: PMC7483307, 939–949 (Sept. 2020).

CAUSE: Bayesian method for MR estimation accounting for correlated pleiotropy

Morrison, J., Knoblauch, N., Marcus, J. H., Stephens, M. & He, X. Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics. en. Nature Genetics 52. PMCID: PMC7343608, 740–747 (July 2020). Journal Link; Preprint; R-package

2018

Burkart, K. M., Sofer, T., London, S. J., Manichaikul, A., Hartwig, F. P., Yan, Q., Artigas, S., Avila, L., Chen, W., Thomas, S. D., Diaz, A. A., Hall, I. P., Horta, B. L., Kaplan, R. C., Laurie, C. C., Menezes, A. M., Morrison, J. V., Oelsner, E. C., Rastogi, D., Rich, S. S., Soto-quiros, M., Stilp, A. M., Tobin, M. D., Wain, L. V., Celed, J. C. & Barr, R. G. A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function The Hispanic Community Health Study/Study of Latinos. American Journal of Respiratory and Critical Care Medicine 198. PMCID: PMC6058984, 208–219 (2018).

Liu, Y., Liang, Y., Cicek, A., Li, Z., Li, J., Muhle, R., Krenzer, M., Mei, Y., Wang, Y., Knoblauch, N., Morrison, J., Zhao, S., Jiang, Y., Geller, E., Ionita-Laza, I., Wu, J., Xia, K., Noonan, J., Sun, Z. & He, X. A Statistical Framework for Mapping Risk Genes from De Novo Mutations in Whole-Genome-Sequencing Studies. American Journal of Human Genetics 12. PMCID: PMC5992125, 1031–1047 (2018).

Rank conditional coverage: selection adjusted confidence intervals

Morrison, J. & Simon, N. Rank Conditional Coverage and Confidence Intervals in High Dimen- sional Problems. Journal of Computational and Graphical Statistics 27. PMCID: PMC6364309, 648–656 (2018).

2017

Hodonsky, C., Jain, D., Schick, U., Morrison, J., Brown, L., McHugh, C., Schurmann, C., Chen, D., Liu, Y., Auer, P., Laurie, C., Taylor, K., Browning, B., Li, Y., Papanicolaou, G., Rotter, J., Kurita, R., Nakamura, Y., Browning, S., Loos, R., North, K., Laurie, C., Thornton, T., Pankratz, N., Bauer, D., Sofer, T. & Reiner, A. Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos. PLoS Genetics 13. PMCID: PMC5428979 (2017).

Jain, D., Hodonsky, C. J., Schick, U. M., Morrison, J. V., Brown, L., Schurmann, C., Liu, Y., Auer, P. L., Laurie, C. A., Taylor, K. D., Browning, B., Papanicolaou, G., Browning, S. R., Loos, R. J., North, K. E., Thyagarajan, B., Laurie, C. C., Thornton, T. A., Sofer, T. & Reiner, A. P. Genome-Wide Association of White Blood Cell Counts in Hispanic/Latino Americans: The Hispanic Community Health Study/Study of Latinos. Human Molecular Genetics 26. PMCID: PMC5968624, 1193–1204 (2017).

2016

Joint Adaptive Differential Estimation: Differential analysis for spatially structured data Morrison, J., Witten, D. & Simon, N. Simultaneous detection and estimation of trait associations with genomic phenotypes. Biostatistics 18. PMCID: PMC6082590, 147–164 (Aug. 2016).

Schick, U. M., Jain, D., Hodonsky, C. J., Morrison, J. V., Davis, J. P., Brown, L., Sofer, T., Conomos, M. P., Schurmann, C., McHugh, C. P., Nelson, S. C., Vadlamudi, S., Stilp, A., Plantinga, A., Baier, L., Bien, S. A., Gogarten, S. M., Laurie, C. A., Taylor, K. D., Liu, Y., Auer, P. L., Franceschini, N., Szpiro, A., Rice, K., Kerr, K. F., Rotter, J. I., Hanson, R. L., Papanicolaou, G., Rich, S. S., Loos, R. J., Browning, B. L., Browning, S. R., Weir, B. S., Laurie, C. C., Mohlke, K. L., North, K. E., Thornton, T. A. & Reiner, A. P. Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans. English. The American Journal of Human Genetics 98. PMCID: PMC4746331, 229–242 (Jan. 2016).

2015

Morrison, J., Laurie, C. C., Marazita, M. L., Sanders, A. E., Offenbacher, S., Salazar, C. R., Conomos, M. P., Thornton, T., Jain, D., Laurie, C. A., Kerr, K. F., Papanicolaou, G., Taylor, K., Kaste, L. M., Beck, J. D. & Shaffer, J. R. Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL). Human Molecular Genetics 25. PMCID: PMC4743689, 807–816 (Dec. 2015).

Hayes, M. G., Urbanek, M., Hivert, M. F., Armstrong, L. L., Morrison, J., Guo, C., Lowe, L. P., Scheftner, D. A., Pluzhnikov, A., Levine, D. M., McHugh, C. P., Ackerman, C. M., Bouchard, L., Brisson, D., Layden, B. T., Mirel, D., Doheny, K. F., Leya, M. V., Lown-Hecht, R. N., Dyer, A. R., Metzger, B. E., Reddy, T. E., Cox, N. J. & Lowe, W. L. dentification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes 62. PMCID: PMC3749326, 3282–3291 (Sept. 2013).

2013

Morrison, J. Characterization and correction of error in genome-wide ibd estimation for samples with population structure. Genetic Epidemiology 37. PMCID: PMC4001853, 635–641 (Sept. 2013).

Urbanek, M., Hayes, M. G., Armstrong, L. L., Morrison, J., Lowe, L. P., Badon, S. E., Scheftner, D., Pluzhnikov, A., Levine, D., Laurie, C. C., McHugh, C., Ackerman, C. M., Mirel, D. B., Doheny, K. F., Guo, C., Scholtens, D. M., Dyer, A. R., Metzger, B. E., Reddy, T. E., Cox, N. J. & Lowe, W. L. The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. Human Molecular Genetics 22. PMCID: PMC3736865, 3583–3596 (Sept. 2013).

2011

Below, J. E., Gamazon, E. R., Morrison, J. V., Konkashbaev, A., Pluzhnikov, A., McKeigue, P. M., Parra, E. J., Elbein, S. C., Hallman, D. M., Nicolae, D. L., Bell, G. I., Cruz, M., Cox, N. J. & Hanis, C. L. Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. Diabetologia 54. PMCID: PMC3761075, 2047–2055 (Aug. 2011).